Um. When you get into Troll romance/relationship stuff I suggest maybe stopping and reading about it at the homestuck wiki before you get info dumped during the comic. IDK. I felt like I understood the system better when I had some prep time to figure it out.

I think you'll probably remain unspoiled unless you specifically go poking around places that might have HS info. I don't really mind spoilers too much so I didn't really worry about it as I went along. Plus, there's been so much art all over my tumblr that I was technically spoiled for stuff like... months ago, but obviously didn't retain much of it.